English name: Loxoprofen Sodium Hydrate
Trade name: loxone in gel
Chinese name: loxoprofen sodium hydrate
Manufacturer: No.13 * * * Pharmaceutical
Drug introduction
loxone in gel (loxoprofen). ロキソニンゲ125231%, Chinese translation: loxoprofen sodium gel) was originally researched by Japan No.13 * * Co., Ltd. and was approved to be listed in Japan on June 9, 21. This product is used for deformative arthritis, myalgia, swelling and pain after trauma. Clinical trials show that the effect is equivalent to that of oral loxoprofen sodium tablets, but the side effects are reduced. Loxoprofen sodium has excellent antipyretic, analgesic and anti-inflammatory effects, and can be widely used in the clinical treatment of rheumatoid arthritis, osteoarthritis and other diseases.
ロキソニンゲ125231%
medicinal classification name
transdermal analgesic and anti-inflammatory agent
approval date: October 21
trade name
LOXONIN GEL
.
chemical name
monosodium 2-{4-[(2-oxoxyl) methyl] phenyl} proponate dihydrate
molecular formula
C15H17NaO3? 2H2O
molecular weight
34.31
structure
characteristics
it is a white to banded yellow-white crystal or crystalline powder.
it is easily soluble in water or methanol, easily soluble in ethanol (95) and hardly soluble in diethyl ether.
the aqueous solutions (1 to 2) do not show car light.
partition factor
partition coefficient k 1-ォクタノール of aqueous phase of organic solvent, and the first solution (pH1.2) 191 -ォクタビ. 87 クロロホルム, the second solution (pH 6.8) .95 < P > Pharmacodynamics < P > Losoprofen sodium hydrate is absorbed from the skin and transformed into an active metabolite -OH body, acute inflammation and chronic inflammation, showing excellent pain.
1. Anti-inflammatory effect
Losoprofen sodium hydrate cataplasm, karagning edema is an acute inflammatory model (rats), and it has obvious anti-inflammatory effect on adjuvant arthritis (rats) and chronic inflammatory model.
2. Analgesic effect
The cataplasm of loxoprofen sodium hydrate showed analgesic effect in Randase Park Jung Su method (rats). In addition, it shows analgesic effect on adjuvant chronic arthritis pain (rats).
indications
anti-inflammatory/analgesic has the following diseases and symptoms
osteoarthritis, muscle pain, post-traumatic swelling and pain
Usage and dosage
According to the symptoms, apply a proper amount of
1% packaging
gel
25g× 1
5g× 1 to the affected area several times a day.